Antimicrobial Resistance (AMR): a Multidisciplinary Approach
At the Sixty-eighth World Health Assembly in May 2015, the World Health Assembly endorsed a Global Action Plan (GAP) to tackle antimicrobial resistance. Implementation is being supported by a tripartite collaboration of World Health Organization, World Organisation for Animal Health (OIE) and the Food and Agriculture Organisation (FAO). The GAP sets out five strategic objectives, which are being mirrored by national action plans around the world. Capacity to act upon these objectives has been identified as requiring strengthening. This LSHTM short course aims to equip delegates with knowledge and tools to address each of the GAP objectives: 1) to improve awareness and understanding of antimicrobial resistance; 2) to strengthen knowledge through surveillance and research; 3) to reduce the incidence of infection; 4) to optimize the use of antimicrobial agents; and 5) develop the economic case for sustainable investment that takes account of the needs of all countries, and increase investment in new medicines, diagnostic tools, vaccines and other interventions.
The course addresses the need to understand multiple aspects of the intractable problem of antimicrobial resistance. It will enable attendees to develop inter-disciplinary, multi-sectorial One Health responses and interventions to reduce the global threat of AMR.
Aims & objectives
This course equips delegates with the knowledge, conceptual frameworks and tools necessary to understand the complex global threat of Antimicrobial Resistance. The course learning reflects a One Health perspective that incorporates multiple disciplines, multiple sectors and national and international level considerations. Specifically, the course will:
- Provide grounding in multiple aspects of antimicrobial resistance as outlined in the WHO Global Action Plan
- Guide participants through the interdisciplinary understanding of AMR from molecular biology to medical anthropology
- To review and analyse a wide range of relevant topics - including definitions, genetics, epidemiology, public health impact, ethics, patient and health worker knowledge, chemical analysis, regulation and potential interventions
- Outline key challenges in developing and implementing interventions
- Equip participants to critically analyse and improve policies and strategies in the low and middle income countries where they work.
- To bring together a diversity of faculty and postgraduate students, interested in the subject to learn and discuss together.
- The history of antibiotics and emergence of antibiotic resistance
- Antibiotic targets and mechanisms of resistance
- Diagnostic laboratory identification of AMR
- Break points and standardisation
- AMR surveillance methods and burden of drug-resistant infections
- Pharmacokinetics, exposure and drug failure
- One health and AMR
- The use of genomics in AMR
- Antibiotic usage and agriculture
- AMR and the environment
- Infection control
- Antimicrobial stewardship
- The role of diagnostics in reducing antibiotic usage
- Role of water, sanitation and hygiene in AMR
- Role of vaccines in reducing AMR
- Novel alternatives to antimicrobials
- Developing new therapies
- Economics of AMR
- Social science aspects of antibiotic use
Teaching methods and course materials
Faculty for the course will include staff from the LSHTM Antimicrobial Resistance Centre who have extensive expertise in many aspects of AMR. Additional external lecturers will be brought in to provide specialist insights.
Teaching will be conducted online through the Moodle learning environment and will include both synchronous and asynchronous lectures, group work, and opportunities for participatory learning. The course materials, including lecture notes and PowerPoint presentations, key references and other programme support materials will be provided electronically.
The course will be full time for 5 days. The course will be limited to a maximum of 40 participants.
As the course this year will run online, applicants must commit to complete the course during the designated week (4 - 8 July). Lecturers and recordings will not be available beyond that period.
The course is aimed at those designing, implementing and evaluating strategies to address AMR. For example, the course would be relevant for members of National Action Plan committees, policy and practice professionals who are required to address and support AMR initiatives, mid-career scientists and postgraduate students, and clinicians who would benefit from an understanding of the public health importance of AMR and actions to tackle the problem. The course will have a specific focus on AMR in low- and middle-income countries. Applicants should have a good command of English, as all teaching will be in English.