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Found 18 results

Analysing the genetics of tsetse populations to improve planning, monitoring and evaluation of vector control programs

Pharmacodynamics of Intracellular Pathogens for the optimization and/or development of new treatments

Tropical Disease Biology

This is an exciting opportunity to work with one or more intracellular pathogens including Plasmodium, Mycobacterium tuberculosis, Salmonella, N. gonorrhoeae and Chlamydia trachomatis.

The use of a human challenge model to test pneumococcal vaccine efficacy in Malawi

Clinical Sciences

The pneumococcal conjugate vaccine (PCV13) was introduced in Malawi in 2012. Contrary to expectation, the vaccine did not result in reduced pneumococcal carriage in vaccines...

Risk mapping and environmental delineation of filariasis transmission hotspots in Central Africa

Tropical Disease Biology

Onchocerciasis (river blindness) is a neglected tropical disease (NTD) targeted for global elimination.

Development of new therapeutics to tackle snakebite-induced local tissue damage

Tropical Disease Biology

This project will explore the potential utility of small molecules as community-based therapeutics to prevent local tissue damage following snakebite, and thus reduce venom-induced morbidity.

The role of toxin-antitoxin systems in plasmid host range in the framework of the current global antimicrobial resistance crisis

Tropical Disease Biology

The candidate will have access to a large collection of bacterial isolates from relevant hospital diagnostic and environmental samples and will apply comparative genomics...

Looking for a moving needle in a haystack: identifying environmental niches of Salmonella Typhi using shotgun metagenomics

Clinical Sciences

This project is embedded within a Gates study on environmental reservoirs of S. Typhi, using genomic analysis to evaluate strain diversity and ecological distribution with respect to public health.

Modelling cardiovascular responses during treatment for sepsis – a data-rich longitudinal analysis to determine what mediates the harm from aggressive fluid resuscitation in Malawi

Clinical Sciences

We will test mediators of fluid resuscitation success in sepsis in Africa, examining biologically plausible hypotheses.

Imaging the life and death of filarial parasites

Tropical Disease Biology

The student will exploit new transgenic tools to introduce mobile genetic elements encoding fluorescent and luminescent proteins into the genome of the filarial parasite Brugia malayi.

New malaria control products: investigating mosquito insecticide interactions to improve malaria control

This project will investigate how these insecticides interact with mosquitoes in order to inform and help develop better strategies to reduce the risk of insecticide resistance development.

Research into novel therapeutics and drug resistance of tropical infectious diseases

Tropical Disease Biology

This is an exciting opportunity to work in the area of therapeutics and drug resistance of tropical infectious diseases.

Solving malaria diagnostic resistance

Tropical Disease Biology

This applicant will work on analysing the scale of the HRP2 problem, and developing alternative tests to the standard HRP2 RDTs with our industry partners.

Molecular epidemiology of intestinal schistosomiasis and giardiasis in Kimi and Ngamba islands, Lake Victoria

Tropical Disease Biology

This project is set within a ‘One Health’ perspective, with an aim to provide a deeper, more holistic insight into the micro-epidemiology of intestinal schistosomiasis and giardiasis.

Understanding the evolutionary space for the development of insecticide resistance

This project looks to develop a form of accelerated evolution in vivo, to actively generate as wide a range of target site variants as possible.

Bayesian model averaging approach to development of prognostic models

Clinical Sciences

Regression models are widely used in medical research to identify important risk factors of morbidity and mortality.

Analysing the genetics of tsetse populations to improve planning, monitoring and evaluation of vector control programs

The project will use whole-genome sequencing (WGS) data to calculate effective population size from pre- and post-intervention collections of tsetse.

One Wolbachia to rule them all? Testing divergence in the symbiotic biology of clade C and clade D Wolbachia during filarial parasite development

Tropical Disease Biology

The student will investigate comparative biology of a clade D Wolbachia within the veterinary and human zoonotic filarial parasite

The surveillance and mapping of snakebite in sub-Saharan Africa

Clinical Sciences

This project aims to develop and pilot an innovative snakebite surveillance system that is timely, complete and cost-efficient, which feeds into a ‘snakebite dashboard’.